螨变应原及其皮内反应

SKIN REACTION TO DERMATOPHAG IDES ALLERGEN

本文针对研究鼻变态反应迟发型(LR)为主要目的,用螨变应原作皮内试验,HD变应原为对照,对变应原皮内反应三型:速发型(IR)、迟发型(LR)及迟延型(DR)加以观察,并对皮内反应与其他因素的关系分析探讨.发现螨变应原LR者明显高于HD变应原LR者,同时发现皮内反应LR者临床重症率高,且LR者受年龄影响.而血嗜酸性细胞及IgE与LR反应成逆向相关性.

It is well know that there are three types of bronchial reaction in asthma; immediate response (IR) , late response (LR) and delayed response (DR).It is also reported that similar responses are seen in the skin.In this study, we examined the three types of skin reaction to dermatophagoides allergen in 111 subjects.30 cases (27%) had a LR, 39 cases (35.1%) had a DR for skin test against dermatophagoid-es allergen.In comparison, only 15 of 140 cases (10.7%) of HD allergen showed a position LR for the HD skin test and 5 (3.6%) a DR for the HD skia test.There was correlation between late onset skin response and severity of nasal symptoms. Late onset skin tests tended to be positive for elder patients. Eosinophils and IgE levels tended to be lower in the LR positive cases. These findings seem to warrant an exemination of the correlation between skin and nasal responses