癌症患者血清唾液酸、岩藻糖及急性期蛋白含量的观察

OBSERVATION OF SERUM SIALIC ACID, FUCOSE AND ACUTE PHASE PROTEINS CONTENTS IN PATIENTS WITH CANCER

本文对64例原发性肝细胞性肝癌、63例鼻咽癌、34例喉癌、20例胃癌、16例结肠直肠癌、60例良性疾患及58例正常人血清唾液酸(SA)、岩藻糖(Fuc)及五种急性期蛋白[α_1-酸性糖蛋白(α_1-AG)、α_1-抗胰蛋白酶(α_1-AT)、触珠蛋白(HP)、前白蛋白(PA)及转铁蛋白(TF)]含量同时进行测定.结果发现五个癌症组患者血清SA、Fuc、α_1-AG、α_1-AT及HP均非常显著地高于正常人,五个癌症组中,除喉癌组患者血清Fuc与良性疾患无统计学差异外,其他各癌症组患者的这五项指标均非常显著地高于良性疾患.因此.可将上述五项指标视为癌症患者非器官特异性血清肿瘤标志物.此外,还发现鼻咽癌、喉癌Ⅲ、Ⅳ期患者血清SA、Fuc、α_1-AG、α_1-AT及HP均明显高于正常人及Ⅰ、Ⅱ期患者,而且越到后期,升高越明显,这充分说明这五项指标的变化有助于鼻咽癌、喉癌的临床诊断。

Serum contents of sialic acid(SA) , fucose(Fuc), α1-acid glycoprotein(α1-AG), α1-antitrypsin (α1-AT), haptoglobin (HP), prealbumin (PA) and transferrin (TF) were concomitantly measured in 64 patients with primary hepatocellular carcinoma, 63 with nasopharyngeal carcinoma (NPC) , 34 with larygocarcinoma (LC), 20 with gastric carcinoma, 16 with colorectal carcinoma, 60 with benign diseases (BD) and 58 normal blood donors (NBD). The results revealed that serum SA, Fuc, α1-AG, α1-AT and HP contents were all significantly elevated in patients with tne five kinds of cancers mentioned above as compared with NBD.The serum index levels in the five groups Were all significantly higher except in patients with LC than in those with BD. Therefore, measurements of these five indeces are suggested in the non-organic specific serum tumor markers. Furthermore, those five index levels were all significantly higher in patients with Ⅲ, IV phase NPC and LC than in NBD and Ⅰ, Ⅱ NPC and LC. The later the stage was, the more the contents of the five indeces are. The experiment results indicate that the five indeces will help clinical diagnosis, prognosis, therapeutic evaluation