小而密低密度脂蛋白的研究进展被引量：8

Research progress of small low-density lipoprotein

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摘要血浆低密度脂蛋白 (lipoproteinLDL)具有异质性 ,由一系列大小、密度和化学组成各异的颗粒组成。血浆甘油三酯水平越高 ,生成的小而密LDL越多。近年来对LDL亚组份与冠心病的关系进行了深入的研究 ,认为小而密LDL在动脉粥样硬化的发生中起重要作用 ,是冠心病的危险因子。小而密LDL亚组分比密度较低的较大颗粒更具有致动脉硬化性 ,可能与其更易被氧化、诱导内皮细胞表达粘附因子有关。 Low-density lipoproteins are hererogeneous in terms of size and density. The presence of sLDL is associated with raised triglyceride and may be a risk marker for coronary artery disease. Small dense LDL particles have been proved to be more atherogenic than large LDL particles. Antioxidant content of sLDL decresed in comparson with large and buoyant LDL, can enhance the expression of cell adhesion molecules. This property may be proposed to contribute to increase disease risk of atherogenic.

作者秦彦文王绿娅

机构地区北京安贞医院

出处《中国临床药理学与治疗学》 CAS CSCD 2004年第4期370-373,共4页 Chinese Journal of Clinical Pharmacology and Therapeutics

基金北京市科委重点实验室项目 (№ 95 3 85 0 70 0 3 )

关键词低密度脂蛋白动脉粥样硬化细胞粘附分子甘油三酯小而密LDL lipoprotein atherosclerosis cell adhesion triglyceride small low-density lipoprotein

分类号 R543 [医药卫生—心血管疾病]

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