他汀类药物的血压调节作用

Blood pressure regulation of statins

他汀类药物是治疗高胆固醇血症的首选药物 ,临床已广泛应用于血脂异常的治疗。近年来 ,临床研究发现他汀类药物可改善高血压合并血脂异常患者的血压 ,这种作用不仅见于未经治疗的高血压患者 ,对于已经使用抗高血压药物治疗的高血压患者也有一定的疗效。但有一些研究并不完全肯定这一作用。他汀类药物降低血压的作用在很大程度上不依赖于其调脂作用 ,可能与其改善血管内皮功能及调节血管紧张素受体有关。

Statins is first choice of hypercholesteroiemia. Recently, clinical investigations have shown that statins can correct blood pressure in hypertension patients accompanied with lipid abnormalities. This result can be observed not only in untreated patients but also in patients treated with antihypertensive drugs. But some researches did not support this result completely. To some extend, the mechanisms responsible for the hypotensive effect seem to be largely independent on the effect of statins on lipid profile, and may be related to the improvement of endothelial function and the regulation of angiotensin II receptors.