胫腓骨骨折肢体肿胀的3种药物治疗方案的成本-效果分析

Cost-effectiveness Analysis of Three Pharmacotherapeutic Schemes for Limb Swelling Resulting from Fractures of Tibia and Fibula

目的 :探讨不同药物治疗方案对胫腓骨骨折所致肢体肿胀的经济效果。方法 :选取胫腓骨骨折病例58例 ,分为A组 (甘露醇 )、B组 (七叶皂苷钠 )、C组 (联合用药 ) ,观察肢体肿胀消退的程度和治疗时间。运用药物经济学成本 -效果分析方法进行比较。结果 :各方案单位效果所需成本分别为15 06元、20 77元、17 71元 ;在A组的基础上 ,B组和C组增加单位效果所需成本分别为98 92元、36 25元。结论 :C组有效率高 ,而且增加单位效果所需成本较低。因此 ,联合用药是最为合理的方案。

OBJECTIVE:To discuss the economic effects of different pharmacotherapeutic schemes for limb swelling reˉsulting from fractures of tibia and fibula.METHODS:The clinical data of58cases of fractures of tibia and fibula were collected and divided into three groups:group Amannitol,group Bsodium aescinate,and group Csodium aescinate and mannitol. The extinctive degree of limb swelling and treatment duration were observed.Data were evaluated using the pharmacoeconomic costeffectiveness analysis.RESULTS:Three schemes costed15.06,20.77and17.71yuans respectively for increasing1%of effective rate.On the basis of group A,group B and C costed98.92and36.25yuans respectively for increasing1%of effective rate.CONCLUSION:The effective rate of group C was markedly higher than those of group A and B.When increasing the same efficacy,group C cost lower expense than group B.So the combined use of sodium aescinate and mannitol is most reaˉsonable.