男性乳腺癌的治疗及预后因素分析:附37例报告

The treatment and prognosis of male patients with breast cancer:a report of 37 cases

目的 探讨男性乳腺癌 (MBC )的治疗和预后因素。方法 回顾性分析 3 7例男性乳腺癌的临床资料。手术方式包括经典根治术 (10例 ) ,改良根治术 (19例 ) ,单纯乳房切除术 +同侧腋窝淋巴结摘除术 (4例 ) ,单纯乳房切除术 (4例 )等。结果 上述手术方式的患者 5年生存率依次为 80 .0 %,78.9%,2 5 .0 %,2 5 .0 %;腋窝淋巴结有转移和无转移的患者 5年生存率分别为 5 0 .0 %和 93 .3 %;雌激素受体 (ER)阳性和阴性的患者 5年生存率分别是 80 .0 %和 42 .8%(P <0 .0 5 ) ;结论 改良根治术是MBC的首选术式 ,术后可根据情况辅以其他治疗 ;腋窝淋巴结转移、病理类型及肿瘤分期等因素影响预后 ,其中手术方式和腋窝淋巴结状况为影响预后的主要因素。

Objective To study the treatment and prognosis factor of male breast cancer(MBC). Methods The clinical data of 37 male cases of breast cancer were analyzed retrospectively.All the patrents underwent operation , including radical mastectomy(10cases), modified radical mastectomy(19cases),simple mastectomy plus axillary lymph node extirpation(4cases) and mastectomy (4cases).Results the 5-year survival rate of operation mentioned above were 80.0% ,78.9%,25.0%,25.0%, respectively. The 5 years survival rate in patients with axillary lymph node metastasis and without metastasis were 50.0% and 93.3%( P <0.05);in ER positive and negative were 80.0% ,42.8%( P <0.05)respectirely.Conclusions The modified radical mastectomy is the first choice of treatment of MBC, and other adjacent treatment may be needed postoperatively according to patients' condition . The influence factors of prognosis of MBC are the status of axillary lymph node, pathological type, and tumor stage of TNM.Among these factors, operative procedure and the status of axillary lymph node are the main factors .