氦氖激光血管内照射治疗氯氮平所致脂类代谢异常

Effect of intravascular He-Ne laser irradiation on the abnormal lipid metabolism induced by clozapine

目的观察氦氖激光血管内照射 (ILIB)治疗氯氮平所致脂类代谢异常的疗效和副作用。方法 5 2例精神分裂症患者(男性 3 4例、女性 18例 )单一服用氯氮平 ,剂量 2 0 0— 3 5 0mg/d。患者隔天接受ILIB治疗 1次 ,60min/次 ,10次为 1个疗程。于ILIB治疗前后检查患者的脂类代谢、肝、肾功能和凝血功能。结果接受ILIB治疗后 ,患者的TC、TG、LDL ch较治疗前下降 (P <0 .0 5 ) ,HDL ch较治疗前明显升高 (P <0 .0 1) ,肝、肾功能、凝血功能均未发现异常。结论ILIB治疗氯氮平所致脂类代谢异常有效 ,且安全 ,有临床应用价值。

ObjectiveTo observe the effect and side effect of intravascular He-Ne laser irradiation (ILIB) on the abnormal lipid metabolism induced by clozapine.Methods52 patients with schizophrenia (34 males, 18 females) took clozapine alone at a dosage of 200-350 mg/d. All patients were treated with ILIB every other day, 60 min once, ten times altogether. Before and after treatment, lipid metabolism, liver, kidney and blood coagulate functions of patients were tested.ResultsTC, TG, LDL-ch levels of patients decreased obviously after ILIB treatment ( P<0.05), while HDL-ch level increased obviously ( P<0.01). The liver, kidney and blood coagulate functions were as same as before treatment.ConclusionILIB has an extreme effect on the abnormal lipid metabolism induced by clozapine, and it is quite safe and has clinical practice value.