血管性痴呆患者行为干预的研究

The Study on Behavioral Intervention of Patients with Vascular Dementia

目的 探讨血管性痴呆 (VD)患者认知功能康复训练效果。方法 将 172例轻、中度VD(简易智能状态量表 (MMSE) 10～ 2 4分 )患者进行随机 12周行为干预临床研究 ,其中90例为单盲对照研究 ,82例为自身对照干预研究。结果 随机、单盲干预组较对照组MMSE、日常生活自理量表 (ADL)分数显著改善 ,P <0 .0 1;自身对照干预组研究结果显示 ,干预 4周后 ,MMSE、ADL分数已有改善 ,P <0 .0 5 ,12周后MMSE、ADL分数有显著改善 ,P<0 .0 1。结论 持续有计划地对轻、中度VD患者进行行为干预训练 ,对VD患者的认知功能和日常生活自理能力均有明显改善。此训练经济、方便 ,患者及家属容易接受和坚持。

Objective To investigate the effect and method of cognitive rehabilitation exercise of patients with vascular dementia (VD). Methods 172 cases with slight and moderate VD who were tested with Mini-Mental State Examination (MMSE) and got scores 10-24 were divided into randomized single-blind study group (n=90) and auto-control group (n=82), Each group received behavioral intervention exercise for 12 weeks. Results The scores tested with MMSE and Activity of Daily Living Scale (ADL) in randomized single-blind study group were changed significantly than that in control group; In auto-control group the scores of MMSE and ADL were changed in 4 weeks (P<0.05) and changed significantly in 12 weeks (p<0.01). Conclusions Continuous and designed behavioral intervention is benefit for patients with slight and moderate VD and can improve their cognitive function and ability of daily living.