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非离子型X线造影剂碘佛醇的合成 被引量:10

Synthesis of ioversol,a non-ionic x-ray contrast agent
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摘要 目的:合成非离子型X线造影剂碘佛醇。方法:以自制的5-氨基-N,N’-双(2,3-二羟丙基)-2,4,6-三碘-1,3-苯二甲酰胺为原料,经氯酰化、水解和氮烷基化反应制得碘佛醇粗品;碘佛醇粗品的纯化分别采用甲醇、732和717树脂处理,再用丁醇重结晶。结果:产品经元素分析、红外光谱、核磁共振谱和质谱鉴定与碘佛醇结构一致。结论:该方法操作简便,适于工业化生产。 Objective:To synthesize ioversol,a non-ionic x-ray contrast agent. Methods: loversol was synthesized by choloracetylation, dechlorination, and alkylation of 5-amino-N,N '-bis(2,3-dihy-droxypropyl)-2,4,6-triiodoisophthalamide.The crude product was treated with methanol,732 and 717 resins successionally and purified by recrystallization from butanol. Results: That the structure of the product obtained by the process was confirmed by IR,1H-NMR,13CNMR,MS (FAB) and elemental analysis. Conclusion: A simple and convenient method for synthesis of ioversol is provided and it is suitable for pharmaceutical industry.
出处 《中国新药杂志》 CAS CSCD 北大核心 2004年第4期338-340,共3页 Chinese Journal of New Drugs
基金 江苏省科技厅科研项目(BJ2000048) 江苏省卫生厅科研项目(H9810)
关键词 非离子型X线造影剂 碘佛醇 合成 non-ionic x-ray contrast agent ioversol synthesis
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参考文献5

  • 1Lin YL, Chesferfield MO. Triiodoisphthalamide X-ray contrast agent[P]. USP:4396589,1983 - 08 - 02.
  • 2Mccarthy WZ. Process for preparation of ioversol [P]. USP:4997983,1991 - 05 - 05.
  • 3Mccarthy WZ,Knerller MT,Lin YL,et al. Synthesis of ioversol using chloroacetyl chloride[P]. USP: 5177261,1993 - 01 - 05.
  • 4Dunn TJ, White DH. Process for producing ioversol [P]. USP:5648536,1997 - 07 - 15.
  • 5罗世能 谢敏浩 刘娅灵.一种碘海醇的制备方法[P].中国专利ZL:95112779.9.2002-01-23.

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同被引文献45

  • 1刘娅灵,罗世能,邹霈,谢敏浩,何拥军,王德杭,潘溪江.X线造影剂碘佛醇注射液的制备及动物造影实验[J].中国现代应用药学,2005,22(2):100-102. 被引量:3
  • 2罗世能,谢敏浩,奚月芬,张满达,孟虹,刘娅灵,黄荷云,邹霈.非离子型X-CT造影剂碘海醇的合成[J].中国医药工业杂志,1995,26(10):433-435. 被引量:21
  • 3赵景宏,黄岚,王军平,晋军,宋耀明,陈剑飞,武晓静,周健,于世勇.高渗和低渗造影剂对大鼠肾动脉内皮功能的影响及意义[J].第三军医大学学报,2006,28(16):1713-1715. 被引量:8
  • 4Lin YL, Chesferfield MO. Triiodoisphthalamide X-ray contrast agent: US,4396589[ P]. 1983-08-02.
  • 5McCarthy WZ, Knerller MT, Lin YL, et al. Synthesis of ioversol using chloroacetyl chloride : US,5177261 [ P ]. 1993-01-05.
  • 6Doran , NO. , Dunn TJ, et al. Reversed phase chromatographic process : US,5204005 [ P].1993-04-20.
  • 7Kneller, MT. Purification of crude ioversol using continuous dcionixation : US,5210300 [ P].1993-05-11.
  • 8Bosworth, ME, Dunn TJ, et al. Purification of crude ioversol using reverse osmosis : US ,5160437 [ P]. 1992-11-03.
  • 9Bosworth, ME , Dunn TJ, et al. Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis : US ,5221485 [P]. 1993 -06-22.
  • 10Anelli Pier Lucio, Brocchetta Marino, et al. A process for the preparation of iopamidol and the new intermadiates therein :W0,0244132[P].2002-06-06.

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