手术为主治疗卵巢上皮癌156例临床分析

Clinical study on treatment based on surgery in 156 cases of epithelial carcinoma of ovary

目的探讨手术治疗对上皮性卵巢癌预后的影响。方法 回顾性分析近10年来收治的有完整统计资料的上皮性卵巢癌156例患者的临床资料。结果 随访至2002年12月,5年生存率为57.5％(46/80),3年生存率为75.5％(80/106);残余病灶<2 cm者3年和5年生存率分别为50.0％和34.6％,残余病灶>2 cm者分别为20.0％和0;在无手术残余灶的基础上不同术式之间3年和5年生存率相近。结论手术后有无残余病灶及残余灶大小是影响卵巢癌患者预后的主要因素,而手术方式的选择、腹膜后淋巴结清除对预后影响不显著;复发性晚期卵巢癌治疗应选择以二线化疗药物为基础的联合化疗。

Objective To study the influence of operation on the prognosis of epithelial carcinoma of ovary. Methods 156 cases with epithelial carcinoma of ovary treated at our hospital in recent 10 years, whose statistical data were complete, were analyzed retrospectively. Results During followed-up to Dec 2002, the total 5-year survival rate was 57.5% (46/80), and 3-year survival rate was 75.5% (80/106) .The 3-year and 5-year survival rates of the cases who did not have remnant tumor were higher than 70.0% and 50.0% , while those of the cases whose remnant tumors were smaller than 2cm were 50.0% and 34.6% ,and remnant tumors bigger than 2cm were 20.0% and 0, respectively.The 3-year and 5-year survival rates of cases who were treated with different operation methods and did not have remnant tumor were equal. Conclusions Whether there is remnant tumor after operation and the size of remnant tumor are the main prognostic factors, while operation methods and retroperitoneal lymph-adenectomy have insignificant influence on prognosis. The treatment of relapsed advanced ovarian cancer is combined chemotherapy based on second-line chemotherapeutic agent.