西酞普兰与阿米替林治疗抑郁症的临床疗效对照分析

Clinical controlled study of citalopram versus amitriptyline in treatment of depressive disorder

目的 探讨西酞普兰对抑郁症的临床疗效及安全性。方法 将 4 6例抑郁症患者随机分配至西酞普兰组及阿米替林组 (各 2 3例 )。西酞普兰治疗剂量为 2 0～ 4 0mg/ ,1次 /d ,阿米替林为 15 0～ 30 0mg/ ,1次 /d。观察时间均为 6周。疗效评定采用Hamilton抑郁量表 (HAMD)。安全性评价应用TESS、实验室检查及体查。结果 西酞普兰组显效率为 74 % ,有效率为 91% ,与阿米替林组的 6 5 %及 87%相当 ;西酞普兰组不良反应较阿米替林组少且轻微 ,患者依从性好。结论 西酞普兰与阿米替林对抑郁症均有较好的疗效 ,但西酞普兰具有日服剂量小、给药方法简便。

Objective The purpose of this study was to investigate the clinical efficacy and adverse reactions of citalopram in the treatment of depressive disorder.Methods 46 patients with depressive disorder were randomly divided into two groups.The citalopram group of 23 patients was treated with citalopram 20～40mg/d -1 ,po,for 6 wk.The amitriptyline group of 23 patients was treated with amitriptyline 150～300mg/d -1 ,po,for 6 wk.HAMD were adopted to evaluate the efficacy.Safety was evaluate by TESS,laboratory and physical examination.Results After 6 wk treatment,the significant improvement rate and the response rate of citalopram group was 74% and 91%.The significant improvement rate and the response rate of amitriptyline group was 65% and 87% respectively.There were no significant differences between the two groups( P >0.05).However the adverse reactions of citalopram were lower and lighter than amitriptyline.Conclusion The results indicate that both citalopram and amitriptyline is effective in the treatment of depressive disorder,but citalopram showed more advantages for its convenient administration and low daily dosage and the adverse reactions of it were light.