抑郁发作患者的持续性注意功能障碍及其影响因素分析

Influence factors of depressive episode and its sustained attentional dysfunction

目的 探索抑郁发作患者的持续性注意功能障碍及其影响因素。方法 对 30例抑郁发作 (DE)患者进行持续性操作测验 (CPT)检查 ,分析临床症状、药物剂量等因素对CPT指标的影响 ,并以 32例精神正常者 (NC)作为对照。结果 DE中绝大多数的CPT指标 (舍弃数、漏答数、误答数、平均反应时间和变异系数 )均显著高于NC(P <0 0 5～ 0 0 0 1) ;其HAMD总分和绝大多数因子分与CPT指标均无显著相关 ;精神药物剂量 (抗抑郁药丙咪嗪等效剂量 ,镇静催眠药安定等效剂量和抗精神病药氯丙嗪等效剂量 )与CPT指标多无显著相关。结论 抑郁发作患者中存在着持续性注意缺陷。由于这一现象难以完全用临床症状或药物影响等因素来加以解释。因此 。

Objective The purpose of this study was to explore the feature of sustained attention in depressive episode patients.Methods 30 cases of depressive episode in patients(DE) and 32 of normal controls(NC) were examinated with continuous performance test(CPT),and clinical symptoms,drug doses,and etc.In DE were analyzed ,too.Results Most of CPT parameters(number of cancel,number of omission,number of commission,mean reaction time and variance coefficient)in DE were significantly higher than those in NC( P <0.05～0.001).No significant correlation was found between total and almost factor scores in HAMD or the amounts of psychotropic drugs(imipramine equivalent dose of antidepressants,diazepam equivalent dose of sedatives,chlorpromazine equivalent dose of antipsychotics) and CPT parameters.Conclusion Deficits in sustained attention in depressive episode patients were remarkable.Because it was difficulty to explain these deficits with the influences by clinical symptoms,drugs,and etc.,our results supported that this deficit in sustained attention might be a hereditary marker of this disorder.