偏执型精神分裂症患者的血一氧化氮水平研究

A study of serum nitric monoxide level in paranoid schizophrenics.

目的 了解偏执型精神分裂症患者的血一氧化氮水平及其与临床症状间的关系。方法 对 32例偏执型精神分裂症患者的血一氧化氮水平进行了检测 ,采用阳性和阴性症状量表 (PANSS)对其临床精神病理症状进行评定。结果 患者组一氧化氮水平 (6 7.79± 2 3.0 6umol/L)高于对照组 (4 8.78± 16 .0 2umol/L) (t =3.4 6P <0 .0 0 2 ) ,一氧化氮水平与PANSS总分及各因子分未发现相关关系 (r =0 .0 5 5 0 .0 2 4 0 .0 17 0 .0 71 P >0 .0 5 )。结论 偏执型精神分裂症患者的血一氧化氮高 ,并可能是偏执型精神分裂症的病理基础。

Objective To explore the serum nitric monoxide level in paranoid schizophrenics and its relationship with clinical symptoms.Methods The serum nitric monoxide level of 32 paranoid schizophrenics was detected.Clinical symptoms were rated by Positive and Negative Syndromes Scale(PANSS).Results The serum nitric monoxide level of paranoid schizophrenics was higher than that of normal controls (P<0.002).The serum nitric monoxide level was not correlated with total or Subscale of PANSS(r=0.055 0.024 0.017 0.071 P>0.05).Conclusion There is high serum nitric monoxide level in paranoid schizophrenics.It may be one of pathologic basis to paranoid schizophrenia.