万拉法新、阿米替林、氟西汀治疗抑郁症的对照研究

A comparative study of venlafaxine、amitriptyline and fluoxetine in the treatment of depression.

目的 比较万拉法新、阿米替林和氟西汀治疗门诊抑郁症的疗效和副反应。方法 对符合CCMD Ⅲ抑郁发作诊断标准的患者随机分为三组 ,分别给以万拉法新、阿米替林及氟西汀治疗 ,治疗疗程为 6周 ,用Hamilton抑郁量表 (HAMD) ,临床大体印象量表 (CGI)、副反应量表 (TESS)进行评分。结果 治疗 6周后的显效率万拉法新组为 75 % ,阿米替林组为 70 % ,氟西汀组为 6 5 % ,差异无显著统计学意义 (χ2 =0 .4 2 P >0 .0 5 )。万拉法新组显效快 ,2周内的HAMD总分低于阿米替林和氟西汀组 ,差异有显著统计学意义 (F =5 .2 4 P <0 .0 1)。阿米替林组的副反应明显多于万拉法新和氟西汀组。结论 万拉法新是一种疗效较好而副反应较少的抗抑郁药。

Objective To explore clinical efficacy and side effects among venlafaxine.amitriptyline and fluoxefine in the treatment of depression in outpatients.Methods Sixty patients who met CCMD-3 criteria for depression were randomly assigned to 3 groups. One group was treated with venlafaxine,the second with amitriptyline and the third with fluoxetine for 6 weeks.Hamilton Rating Scale (HAMD),Clinical Global Impression scale (CGI) and Treatment Emergent Symptom Scale (TESS) were used to assess efficacy and side effects.Results Total clinical effective rate was 75% for venlafaxine group,70% for amitriptyline group and 65% for fluoxitine group after 6 weeks.There were no significant diferences on clinical effecacy among the 3 groups (χ 2=0.42 P>0.05).However, the total score of HAMD in the venlafaxine group was significantly lower than that in the amitriptyline and fluoxetine groups after 2 weeks(F=5.24 P<0.01).The side effects of amitriptyline were significantly more than those of venlafaxine and fluoxetine.Conclusion The results indicate that venlafaxine was a safe and effective drug for the treatment of depression.