抑郁症患者血清同型半胱氨酸水平的研究

Serum level of homocysteine in depressive patients.

目的 探讨同型半胱氨酸 (Homocysteine ,Hcy)在抑郁症发病中的作用。方法 采用荧光偏振免疫法 (FPLA)检测 2 2例抑郁症患者 (抑郁症组 )和 2 0名正常人 (对照组 )的血清Hcy水平 ,以 μmol/l计。 结果 抑郁症组血清Hcy水平高于对照组 [(16 .37± 6 .4 5 ) μmol/l比 (11.6 2± 4 .0 7) μmol/l,P <0 .0 1]。抑郁症组高同型半胱氨酸血症 (Hyperhomocysteinemia ,HHcy) (血清Hcy水平 >16 .0 0 μmlo/l)的发生率明显高于对照组 (4 5 .4 5 %比 10 .0 0 % ,oddsratio ,7.5 ;95 %可信区间 ,1.5 9～ 35 .39,P <0 .0 5 )。结论 抑郁症患者的血清Hcy水平升高 ,提示Hcy在抑郁症的发病中起一定作用。

Objective To investigate the association between homocysteine and depression.Methods Serum level of homocysteine was measured in 22 patients with depression and 20 normal controls by fluorescence polarization immunoassay(FPIA).Results Hcy concentration in patient group was significantly higher than that in the control group [(16.37±6.45)μmol/l vs (11.62±4.07)μmol/l,P<0.01].There was a significantly higher incidence of hyperhomocysteinemia(HHcy) in patient group than that in control group(45.45% vs 10.00%,odds ratio,7.5;95% confidence interval,1.59～35.39,P<0.05).Conclusion It is suggested that homocysteine played a role in pathogenesis of depression.