右旋布洛芬缓释胶囊在比格犬体内的药物动力学

Evaluation of the pharmacokinetics of dexibuprofen modified-release capsules in Beagle dog

目的建立一种快速、专属的HPLC UV法用于测定比格犬血浆中右旋布洛芬的浓度 ,应用本法对右旋布洛芬缓释胶囊在比格犬体内的药物动力学行为进行研究。方法 8只比格犬采用双周期交叉试验设计 ,分别口服给予右旋布洛芬缓释胶囊 (受试制剂 )及清芬片 (右旋布洛芬片 ,参比制剂 )后按时间点采集血样进行分析 ,绘制血药质量浓度 时间曲线 ,计算相关药动学参数。结果经统计分析 ,两种制剂间药动学参数AUC0 -t、AUC0 -∞ 无显著性差异 ,受试制剂峰质量浓度 ρmax低于参比制剂 ,tmax显著增大。

Objective To develop a rapid and specific HPLC-UV method for the determination of dexibuprofen in Beagle dog plasma,and use it to investigate the pharmacokinetics of dexibuprofen in Beagle dog plasma.Method A single dose,two periods,cross-over study in 8 Beagle dogs was carried out.After an oral dose of dexibuprofen modified-release capsules (test) or Qingfen tablets (reference),the plasma samples were drawn and analyzed.Results There were no significant difference in AUC 0-t and AUC 0-∞ between the two preparations,but ρ max of the test preparation was less than the reference one and t max was obviously larger than it.Conclusion The release of the test preparation dexibuprofen modified-release capsules is modified.