左旋泮托拉唑镁对动物实验性胃溃疡的影响

Effect of (-)-pantoprazole magnesium on experimental gastric ulcer

目的研究左旋泮托拉唑镁 ((- ) PAN·Mg)对动物实验性胃溃疡的影响。方法应用小鼠束水应激型胃溃疡模型、小鼠阿斯匹林型胃溃疡模型、大鼠醋酸烧灼型胃溃疡模型、大鼠幽门结扎型胃溃疡模型 ,急性胃瘘大鼠模型 ,观察口服 (- ) PAN·Mg对胃溃疡的抑制作用及对胃酸分泌的影响 ,并与右旋、消旋体进行了比较。结果 (- ) PAN·Mg对动物实验型胃溃疡具有明显的保护作用 ,能显著抑制溃疡的发生 ,抑制胃酸分泌 ,对胃溃疡的抑制效果优于 (+) PAN·Mg和 (± ) PAN·Mg。 结论 (- ) PAN·Mg的抗动物实验性胃溃疡作用和抑酸作用强于右旋 ((+) PAN·Mg)与消旋泮托拉唑镁 ((± ) PAN·Mg) 。

Objective To study the effect of (-)-PAN·Mg on four kinds of experimental gastric ulcer.Methods The inhibitory effect of (-)-PAN·Mg on experimental gastric ulcers:including water immersion restraint stress-induced and aspirin-induced gastric ulcer in mice,acetic acid-induced and pyloric ligated gastric ulcer in rats,and the gastric acid secretion in the model of acute fistula rats were observed,at the same time,compared with (+)-PAN·Mg and (±)-PAN·Mg.Results (-)-PAN·Mg showed marked protective effect on 4 experimental gastric ulcers.(-)-PAN·Mg significantly reduced the gastric ulcerogenesis,gastric acid secretion and more potent than (+)-PAN·Mg and (±)-PAN·Mg in animal models.Conclusion (-)-PAN·Mg was superior to (+)-PAN·Mg and (±)-PAN·Mg in experimental gastric ulcer,have good development prospect.