手性配体1,4-双(9-O-奎宁)-2,3-二氮杂萘的简便合成方法

A simple method for the synthesis of 1,4-bis(9-O-quininyl)phthalazine

在NaH存在下 ,以DMF为溶剂 ,在温和条件下合成了手性配体 1 ,4 双 (9 O 奎宁 ) 2 ,3 二氮杂萘 ,最后用重结晶方法得到纯品 。

The chiral ligand 1,4 bis(9 O quininyl) phthalazine was prepared in a high yield under mild conditions,which used DMF as solvent in the presence of NaH.The pure product was recrystallized by ethyl acetate.This provides a simple way to synthesize the chiral ligand in a large scale.