摘要
2 硝基 4 二氟甲氧基苯胺在Raney Ni催化下被水合肼还原 ,还原产物不经分离直接用于制备标题化合物 ,总收率达到 94 %。方法操作简便 ,安全可靠 ,适合于工业化生产。对另外几种取代的邻硝基苯胺进行了相同的还原试验 ,也取得了理想的结果 ,这为寻找新的具有生理活性的质子泵抑制剂提供了一条安全、有效的途径。
Nitro 4 difluoromethoxyaniline was reduced by hydrazine hydrate in the presence of Raney Ni and followed by cyclocondensation with potassium ethyl xanthate in one pot to give the 2 mercapto 5 difluoromethoxy 1 H benzinidazole with an overall yield of 94%.In addition,the method of the reduction of N (2 nitro 4 difluoromethoxy)phenylamine was extended to several other substituted o nitrophenylamine showing that the process was simple and safe for industrialization.
出处
《化学试剂》
CAS
CSCD
北大核心
2004年第2期101-102,共2页
Chemical Reagents
