番茄汁对D-半乳糖衰老模型大鼠海马神经元的抗衰老作用

Effect of tomato juice against aging of hippocampal neurons in D-galactose induced aging rat model

目的:探讨番茄汁对衰老模型大鼠海马神经元的抗衰老作用。方法:采用随机数字表将30只Wistar大鼠随机分成3组,建立D-半乳糖亚急性衰老模型,采用生化、光镜和电镜等方法,观察番茄汁对衰老大鼠海马神经元的影响。结果:番茄汁组大鼠大脑丙二醛含量犤(3.41±0.36)μmol/g犦,与乳糖组犤(4.01±0.27)μmol/g犦相比显著降低(P<0.05),超氧化物歧化酶(SOD)活性犤(25.06±1.86)NU/mg犦与D-半乳糖组犤(20.63±2.52)NU/mg犦相比明显增高(P<0.01);海马神经元形态结构衰老征象明显减轻。结论:番茄汁可延缓海马神经元的衰老进程,具有一定的抗衰老作用。

AIM:To discuss the role of tomato juice in preventing hippocampal neurons agai nst aging in D-galactose induced aging rats. METHODS:According to random number table,30 Wistar rats were divided into thre e groups at random.D-galatcose induced subacute aging models were established i n rats.Biochemistry,light microscope and electron microscope were used to observ e the effect of tomato juice on hippocampal neurons of aging rats. RESULTS:Compa red with the D-galatcose group[(4.01 ±0.27) μmol/g,(20.63±2.52)NU/mg],the le vels of malondialdehyde was significantly decreased in the tomato juice group[(3 .41±0.36) μmol/g](P< 0.05),however,the activity of superoxide dismutase was si gnificantly increased in the tomato juice group[(25.06±1.86) NU/mg](P< 0.01).Th e aging symptoms of morphological structure of hippocampal neurons were remarkab ly relieved. CONCLUSION:The tomato juice can delay the aging process of hippocampal neurons ,and have a anti-aging role to a certain extent.