摘要
目的 研究砷对雌性大鼠血清中雌二醇 (E2 )、卵泡雌激素及黄体生成素、泌乳素水平及卵巢、肾上腺病理改变的影响。方法 雌性大鼠经砷染毒 10周后用放射免疫法测定血清中激素水平 ;光镜观察子宫和肾上腺的病理改变。结果 除了LH各染毒组与对照组比较有统计学意义外 (P <0 .0 5 ) ,其余各组均无统计学意义 (P >0 .0 5 ) ;但卵巢及肾上腺有不同程度的病理改变。结论 砷对雌性大鼠的内分泌激素LH是一个敏感指标 。
Objective Effects of arsenic on the levels of estradiol(E2), follicle stimulating hormone(FSH), luteinizing hormone (LH) and prolactin (PRL) in serum of female rats, as well as histopathological changes of ovary and adrenal gland were researched. Method\ The hormone levels of female rats were determined by RIA exposing arsenic for 10 weeks, and histopathological examination of ovary and adrenal gland were performed with light microscope. Result\ In spite of LH, there was no levels of three hormones (P> 0.05). However, different extents of histopathological changes in ovary and adrenal gland were found. Conclusion LH is a sensitive index for hormones of female rats, but it may directly damage the reproductive system.
出处
《地方病通报》
2004年第2期17-19,共3页
Endemic Diseases Bulletin
关键词
砷
大鼠
激素
病理组织学
Arsenic
Rats
Hormones
Histopathology
