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Kinetics of the Phenotype and Function of Murine Peritoneal Macrophages Following Acute Inflammation 被引量:1

Kinetics of the Phenotype and Function of Murine Peritoneal Macrophages Following Acute Inflammation
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摘要 This study was undertaken to have a better understand for the process and the underlying mechanisms to limit macrophage activation and population of activated macrophages.A comprehensive kinetics of cytokine production was performed in murine peritoneal macrophages recovered from Balb/c mice at various time during the course of an intraperitoneal injection with thioglycollate (TG).The expression of cell surface molecules such as MHC-Ⅰ,MHC-Ⅱ,B7-1 and B7-2 of these macrophages were also determined by flow cytometry.The present findings of our research suggested that the population of activated macrophages and the activation of macrophages (including cytokines production and expression of cell surface functional molecules) were strictly controlled during inflammation process.This is one of the important mechanisms to retain the host homeostasis.Cellular & Molecular Immunology.2004;1(1):57-62. This study was undertaken to have a better understand for the process and the underlying mechanisms to limit macrophage activation and population of activated macrophages.A comprehensive kinetics of cytokine production was performed in murine peritoneal macrophages recovered from Balb/c mice at various time during the course of an intraperitoneal injection with thioglycollate (TG).The expression of cell surface molecules such as MHC-Ⅰ,MHC-Ⅱ,B7-1 and B7-2 of these macrophages were also determined by flow cytometry.The present findings of our research suggested that the population of activated macrophages and the activation of macrophages (including cytokines production and expression of cell surface functional molecules) were strictly controlled during inflammation process.This is one of the important mechanisms to retain the host homeostasis.Cellular & Molecular Immunology.2004;1(1):57-62.
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2004年第1期57-62,共6页 中国免疫学杂志(英文版)
基金 supported by the National Natural Science Foundation of China,No.A30171086 the Knowledge Innovation Program of Chinese Academy of Sciences and the number is KSCX2-SW-202
关键词 MACROPHAGE CYTOKINE PHENOTYPE SELF-REGULATION macrophage cytokine phenotype self-regulation
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