摘要
The process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V,D,and J segments of the Ig H and L chain gene loci.During early B cell genesis,productive IgH chain gene rearrangement leads to assembly of the pre-B cell receptor(pre-BCR),which acts as an important checkpoint at the pro-B/preB transitional stage.The pre-BCR,transiently expressed by developing precursor B cells, comprises the Ig μH chain,surrogate light(SL)chains VpreB and λ5,as well as the signal-transducing hetero- dimer Igα/Igβ.Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus,stimulates cell proliferation,and induces differentiation to small post-mitotic pre-B cells that further undergo the rearrangement of the IgL chain genes.Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia.Cellular & Molecular Immunology.2004;1(2):89-94.
The process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V,D,and J segments of the Ig H and L chain gene loci.During early B cell genesis,productive IgH chain gene rearrangement leads to assembly of the pre-B cell receptor(pre-BCR),which acts as an important checkpoint at the pro-B/preB transitional stage.The pre-BCR,transiently expressed by developing precursor B cells, comprises the Ig μH chain,surrogate light(SL)chains VpreB and λ5,as well as the signal-transducing hetero- dimer Igα/Igβ.Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus,stimulates cell proliferation,and induces differentiation to small post-mitotic pre-B cells that further undergo the rearrangement of the IgL chain genes.Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia.Cellular & Molecular Immunology.2004;1(2):89-94.
