德清县农村人群戊型肝炎感染状况调查

An Investigation on the Hepatitis E Infection Status in Rural Population of Deqing County

目的 调查德清县农村人群戊型肝炎的感染情况。方法 用ELISA法检测人群中抗 HEVlgG、抗 HEVIgM水平 ,同时调查相关的危险因素。结果 在调查的 85 0名 7岁以上健康人群中 ,抗 HEVIgG ,抗 HEVIgM阳性率分别为 46 3 5 %和 3 0 6%。男女抗 HEVIgG阳性率分别为 5 3 62 %和 3 9 45 % (P <0 0 0 1) ,抗 HEVIgM阳性者中女性较多 (P <0 0 1)。戊型感染可见于各个年龄段 ,但感染率不平衡 ,差异有显著性 (P <0 0 0 1) ,随着年龄的增长感染率有上升的趋势 ,到 45～ 5 5岁年龄组感染率保持在一个稳定水平。结论 德清县农村人群戊型肝炎病毒感染率明显高于国内其他地区报道。感染与性别年龄显著相关 ,男性感染率高于女性 ,随着年龄的增长感染率上升 。

Objective To investigate infection status of hepatitis E virus (HEV) in rural population of Deqing county. Methods Antibodies against HEV (anti HEV) IgG and IgM were tested by enzyme linked immunosorbent assay (ELISA), and the risk factors of hepatitis E infection were investigated. Results Among 850 healthy subjects aged over 7 years old, the positive rates of anti HEV IgG and IgM were 46 35% and 3 06% respectively, the positive rates of anti HEV IgG in males and females, of which difference had statistical significance (P<0 001), were 53 62% and 39 54% respectively, and the positive rate of anti HEV IgM in females was higher than that in males (P<0 01). HEV infection lied in each age group, but the infection rates were not identical, and the difference had statistical significance (P<0 001), which increased with the age, but remained a stable level up to the group of 45～55 years old. Conclusions The infection rate of HEV in rural population of Deqing county is higher than that reported from other domestic districts. The study also shows that HEV infection is significantly associated with sex and age, males tends to suffer from HEV, and the infection rate increases with age, but remains a stable level up to a certain age.