间接法合成2,2-二甲氧基丙烷

Synthesis of 2,2-dimethoxy propane by indirect method

简述了2,2 二甲氧基丙烷(DMP)的合成方法.着重介绍了以乙二醇和丙酮为原料经2,2 二甲基 1,3 二氧环戊烷(DMD)合成DMP的工艺条件.选用二氯甲烷为带水剂,无水硫酸铁为催化剂,经单因素实验合成DMD后,再与甲醇交换,选用AlCl3为催化剂经正交实验合成DMP.两步反应的总收率达到60%.

The synthetic methods of 2,2-dimethoxy propane (DMP) were reported. The technologicl condition of this compound via 2,2-dimethyl-1,3-dioxolane (DMD)was presented briefly, the later compound was prepared on propylene glycol and acetone. In the first stage, choosing dichloromethane as water-separating agent, DMD was synthesized by single factor experiment, then the target product DMP was made under orthogonal design of experiments, AlCl3 as catalyst, DMD was exchanged by methanol, total yield rate of two steps is up to 60 %.