不孕不育患者的免疫因素分析

An analysis of Immunological Factors in Female and Male Infertility

目的 :了解本地区不孕不育患者免疫不孕的因素。方法 :对 1 1 1 5例不孕不育患者用酶联免疫吸附法(ELISA)分别联合测定血清中的AsAb、EmAb、AoAb、HCGAb、ATAb、ACA。结果 :1 74例男性的AsAb阳性率为4 6 .5 5 %。 94 1例女性中 ,六种抗体的阳性率分别为 1 9.34%、1 4 .96 %、1 1 .0 5 %、1 0 .31 %、7.2 6 %和 1 5 .30 %。原发性不孕的AsAb阳性率为 2 2 .33% ;继发性不孕的AsAb阳性率为 1 1 .32 % ,两者比较 χ2 =1 4 .4 7,P <0 .0 1。结论 :在不孕不育临床中最常见的是由于精子免疫引致的男、女性免疫不育 ,尤以原发性不孕为甚 。

Objective:To analyse the factors of immunological infertility in infertile women and men in our area.Methods:Enzyme linked immunoabsorbent assay (ELISA) was carried out to detect anti-sperm antibody(AsAb),anti-endometria antibody (EmAb),anti-ovarian antibody(AoAb),anti-hCG antibody(hCGAb),anti-trophoblast antibody(ATAb),anti-cardiolipin antibody(ACA) in 1115 infertile women and men.Results:The positive rate of AsAb in 174 infertile men was 46.55%.In 941 infertile women,the positive rate of AsAb,EmAb,AoAb,HCGAb,ATAb,ACA was 19.34%,11.05%,10.31%,7.26% and 15.30%,respectively.The positive rates of AsAb in primary stertility and secondary stertility were 22.33%,11.32%,respectively.The positive rate in primary stertility was significantly higher than that in secondary stertility.(χ 2=14.4, P <0.01).Conclusion:Immunological infertility of wemen and men induced by sperm immunoreaction is the commonest in infertility clinical,especially in primary stertility.Diagnosis and treatment of immunological factors in intertile women and men are necessary.