结核分支杆菌1293株的耐药性分析

Analysis on the drug resistance of 1293 tuberculosis mycobacterium strains

目的 分析 1996年以来到福州肺科医院就诊的肺结核病人结核分支杆菌耐药态势 ,为结核病的防治提供依据。方法 应用固体罗氏培养基与快速分离培养技术 (BACTECMGIT 960 )作痰抗酸杆菌培养 ,经菌型鉴定为人型结核分支杆菌者 3 0 0 2株 ,作异烟肼 (INH)、利福平 (RFP)、链霉素 (SM)、乙胺丁醇 (EMB)耐药性测定。结果 3 0 0 2株结核分支杆菌耐药12 93株 ,总耐药率 43 1% ;耐多药 (MDR) 2 5 9株 ,耐多药率 8 6% ,原发及获得性耐多药率分别为 3 9%和 6 9%。耐单药顺位从高到低依次为SM(2 6 3 % ) ,RFP(2 5 5 % ) ,INH(14 3 % ) ,EMB(10 2 % )。耐 2种药及其以上耐药率 2 0 2 % ,MDR耐药率11 6%。各年龄组耐药及耐多药均为青年组 >中年组 >老年组。结论 结核分支杆菌耐药性结果反映了福州地区结核病耐药的基本现状 ,说明结核病患病率仍有升高的危险 ,防治工作任重道远。

To analyze the drug resistance of tuberculosis mycobacterium since 1996 in order to provide basis for the prevention and treatment of tuberculosis. Roch's mass culture medium and BACTEC MGIT 960 were applied to perform sputum culture. 3002 cases were found with human tuberculosis mycobacterium by bacterial typing. Drug resistance determination was made on INH, RFP, SM and EMB. Among the 3 002 tuberculosis mycobacterium, 1 293 have drug resistance with a rate of 43.1%; 259 have multi-drug resistance with a rate of 8.6%; the rate of initial and acquired MDR were 3.9% and 6.9% respectively. The single-drug resistant rate of SM, RFP, INH and EMB were 26.3%, 25.5%, 14.3% and 10.2% respectively. Double-drug resistant rate was 20.2%; the rate of MDR was 11.6%. The rate of drug resistance and MDR in young group is higher than that in the middle-aged group and was even higher than that in the senile group. [Conclusion] The results of the drug resistance of tuberculosis mycobacterium reflected the situation in Fuzhou. It indicates that the morbidity of tuberculosis is likely to rise; prevention work should be strengthened.