裴氏着色霉所致着色芽生菌病深圳首例报告及分析

Chromoblastomycosis Caused by Fonsecaea Pedrosoi:The First Case Report in Shenzhen and Analysis

目的 报告深圳首例裴氏着色霉 (Fonsecaeapedrosoi)所致着色芽生菌病 1例。方法 全面临床检查排除其他疾病 ;皮肤组织病理检查及皮损表面痂皮多次真菌培养、直接镜检证实为着色芽生菌病 ;菌种与标准菌株对照进行培养、鉴定确定为裴氏着色霉 ;临床系统抗真菌治疗观察。结果 组织病理HE染色于表皮角栓内和真皮浅层脓肿内见棕黄色厚壁孢子 (硬壳细胞 )。真菌学培养均为同一菌落生长 (3次 ) ,菌落呈暗棕色 ,绒毛状 ,紧凑感 ,镜下见喙枝孢型分生孢子梗和棕色分枝分隔菌丝。经伊曲康唑和特比萘芬联合治疗辅以高温灯照射 ,5个月后病情明显好转 ,各种真菌学检查阴性。结论 此例着色芽生菌病为深圳特区成立 2 0年来首次发现的病例 。

ObjectiveTo report and analyze the first case of Chromoblastomycosis in Shenzhen. MethodsThe diagnosis was made through histopathology,fu ngal culture and direct examination.The pathogenic fungus was identified after comparison with the reference strain of Fonsecaea pedrosoi.ResultsAbundant sclerotic cells could be found in the sp ecimens taken from infections granulomas.The fungal colonies was dark brown,wo olen state, and compact.Microscopically,branched and septate hyphae and Rhinocla diella type conidiophore could be seen.The patient’s condition was obviously i mproved after combination treatment by itraconazole and terbinafine. ConclusionThe first case of chromoblastomycosis caused b y Fonsecaea pedrosoi in Shenzhen was reported.Combination therapy by itraconazol e and terbinafine was effective in the treatment of chromoblastomycosis.