黄芪对肾病综合征患者氧化应激影响的研究

Effect of Astragalus on Oxidative Stress Status in Primary Nephrotic Syndrome

目的 :探讨原发性肾病综合征 (PNS)患者氧化应激状态以及中药黄芪的抗氧化作用。方法 :4 7例PNS患者随机分为A、B两组 ,分别给予激素和激素加黄芪治疗 ,于治疗前后测定血浆及红细胞丙二醛 (MDA)浓度、红细胞超氧化物歧化酶 (SOD)、全血谷胱甘肽过氧化物酶 (GSH - px)的活性、维生素E(VitE)的含量和主要生化指标。 结果 :与正常对照组比较 ,PNS患者MDA浓度增高 ,SOD、GSH - px活性和VitE含量显著降低 ;与治疗前比较 ,A组氧化应激指标无显著性改变 ,B组患者MDA浓度降低 ,SOD、GSH -px活性增加 (P <0 .0 5 )。结论 :PNS患者氧化应激增强 。

Objective:To investigate the oxidative stress status in patients with primary nephrotic syndrome(PNS) and the antioxidative effects of Astragalus.Methods:47 patients with PNS were randomly divided into group A and B. Group A was treated with corticoid and group B with corticoid and Astragalus.The levels of malondialdehyde(MDA) in plasma and erythrocyte,erythrocyte superoxide dismutase (SOD), blood gluthione peroxidase(GSH-px) and plasma vitamin E were measured before and after treatment.Results:The activity of erythrocyte SOD in patients with PNS was lower than that of normal controls.Furthermore,plasma levels of GSH-px and vitamin E in patients with PNS were lower than those in normal controls.But level of MDA was increased in patients with PNS when compared to that in normal control. After treatment, All the above indexes did not change significantly in group A, but the levels of MDA significantly decreased. The levels of SOD and GSH-px increased significantly in group B(P<0.05).Conclusion:Enhanced oxidative stress occurs in patients with PNS. Astragalus can reduce abnormal oxidative stress in patients with PNS.