高血压伴鼾症患者夜间低氧血症与动态血压关系的研究

Relationship between ambulatory blood pressure and nocturnal hypoxemia in hypertension patients with snoring

目的:探讨高血压伴鼾症患者夜间低氧血症与动态血压变化的关系。方法:对95例高血压伴鼾症患者进行夜间持续经皮血氧饱和度监测,次日行24小时动态血压监测。根据夜间最低血氧饱和度(LSaO2)结果,将患者分为高血压合并低氧血症(EHL)组(51例)及单纯高血压(EH)组(44例),进行两组的一般状况及24小时动态血压各指标对比分析,并进一步行LSaO2、体重指数(BMI)、年龄(Age)与24小时动态血压各指标相关性分析。结果:95例患者中杓型组33例,占34.7%;非杓型组62例,占65.3%。EHL组24hSBP、24hHR、dSBP、dHR、nSBP、nHR、偶测SBP(cSBP)、偶测DBP(cDBP)与EH组相比有显著差异(P<0.05);低氧血症组中84.3%患者动态血压昼夜节律消失。EHL组与EH组血压昼夜节律异常者存在显著性差异(P<0.001)。结论:高血压伴OSAS者血压增高的程度以及血压昼夜节律异常与夜间低氧血症密切相关。

Objective: To explore the relationship between ambulatory blood pressure (ABPM) and nocturnal hypoxemia in hypertension patients with snoring. Methods: A total of 95 hypertension patients with snoring were monitored through continuous oxygen saturation (SaO2) from skin at overall night. The all patients divided as hypertension with night hypoxemia group (EH group, 51 cases) and single hypertension group (EH group, 44 cases) according to level of lowest SaO2. Results: Among 95 patients 33 (34. 7%) were dipper group, 62 (65. 3%) were non-dipper group. The difference of 24h SBP、 24h HR、dSBP、 dHR、 nSBP、 nHR、 cSBP、 cDBP between EH group and EHL group was statistically significant (P<0. 05). The blood pressure day-nocturnal rhythm of 84. 3% patients disappeared in EHL groups. Conclusion: The degree of hypertension and abnormal nocturnal rhythm are close correlated with nocturnal hypoxemia.