老年冠心病碱性成纤维细胞生长因子和纤维连接蛋白的变化

Changes of bFGF and fibronection in aged patients with coronary artery disease

目的:成纤维细胞生长因子(FGF)是一种结构相关的肽生长因子家族,具有很强的促细胞生长作用。本文探讨老年冠心病患者碱性成纤维细胞生长因子(bFGF)、纤维连接蛋白(Fn)的变化及临床意义。方法:对象共42例,冠心病非心绞痛组12例,心绞痛组15例,急性心肌梗死(AMI)组5例,陈旧性心肌梗死组5例,缺血心肌病组5例。用ELISA法测定bFGF、Fn。结果:冠心病非心绞痛组、心绞痛组、AMI组bFGF、Fn分别为177.5±20.2μg/ml,350.2±26.4ug/ml,430.4±8.5tμg/ml;230.3±28.9μg/ml,240.2±27.4μg/ml,360.7±38.4μg/ml,与对照组比较有显著差异(P<0.05-0.01)。结论:bFGF水平:AMI组>心绞痛组>冠心病非心绞痛组。bFGF、Fn对了解冠心病的病情及预后有一定意义。

Objective: To explore the change of basic fibrobrast growth factor (bFGF) and fibronection (Fn) in aged patients with coronary artery disease (CAD). Methods: bFGF and Fn levels were measured in 12 CAD patients no-comlpicated angina pectoris (CADNA group), 15 patients with angina pectoris (AP group), 5 patients with acute myocardial infarction (AMI group) by ELISA method. Results: The levels of bFGF and Fn were 177. 5± 20. 2μg/ml, 350.2±26.4μg/ml. 430.4 ±8. 5μg/ml; 230. 3±28. 9μg/ml, 240. 2±27.4μg/ml, 360. 7± 38.4μg/ml respectively in CADNA group, AP group and AMI group. Their levels significantly increased compared with control group (P<0. 05 -0. 01). Conclusion: Measuring the levels of bFGF and Fn contribute to evaluate CAD patients condition and prognosis.