摘要
AIM: To observe the localization of TRAIL/TRAIR (DR4, DR5,DcR1, DcR2) in the fetal pancreas.METHODS: Fetal pancreas of 32 weeks of pregnancy wereobtained from induced abortions, embedded in paraffin, and4-μm sections were prepared. The localization of TRAIL/TRAILR in fetal pancreas was investigated by fluorescenceimmunohistochemical method combined with laser scanningconfocal microscopy.RESULTS: TRAIL immunoreactive cells were mainly locatedon the periphery of the pancreas islets. There were a fewDcR1 and DcR2 positive cells whereas there were noimmunoreactive cells of DR4 and DR5 in the pancreas islets.In the acini and the ducts of the exocrine pancreas therewere no TRAIL/TRAILR immunoreactive cells.CONCLUSION: This study not only describes thedistribution of TRAIL/TRAILR in the fetal pancreas, but alsoprovides a morphological basis for deducing the functionof TRAIL/TRAILR in pancreas, suggesting that in normalpancreatic islets, the pancreatic cells are resistant towardsapoptosis too.
AIM:To observe the localization of TRAIL/TRAIR(DR4,DR5, DcR1,DcR2)in the fetal pancreas. METHODS:Fetal pancreas of 32 weeks of pregnancy were obtained from induced abortions,embedded in paraffin,and 4-μm sections were prepared,The localization of TRAIL/ TRAILR in fetal pancreas was investigated by fluorescence immunohistochemical method combined with laser scanning confocal microscopy. RESULTS:TRAIL immunoreactive cells were mainly located on the periphery of the pancreas islets.There were a few DcR1 and DcR2 positive cells whereas there were no immunoreactive cells of DR4 and DR5 in the pancreas islets. In the acini and the ducts of the exocrine pancreas there were no TRAIL/TRAILR immunoreactive cells. CONCLUSION:This study not only describes the distribution of TRAIL/TRAILR in the fetal pancreas,but also provides a morphological basis for deducing the function of TRAIL/TRAILR in pancreas,suggesting that in normal pancreatic islets,the pancreatic cells are resistant towards apoptosis too.
基金
the grants of the National Key Basic Research Program of China,No.2001CB510004
