摘要
AIM: To investigate the effects of inhibiting factor of cellcycle regulation p57kip2, retinoblastinoma protein (Rb protein)and proliferating cell nuclear antigen (PCNA) in the genesisand progression of human pancreatic cancer.METHODS: The expression of p57kip2, Rb protein and PCNAin tumor tissues and adjacent tissues of 32 patients withpancreatic cancer was detected with SP immunohistochemicaltechnique.RESULTS: p57kip2 protein positive-expression rate in tumortissues of pancreatic cancer was 46.9 %, which was lowerthan that in adjacent pancreatic tissues (75.0 %) (x2=5.317,P＜0.05), p57kip2 protein positive-expression correlatedsignificantly with tumor cell differentiation (well-differentiationversus moderate or low-differentiation, P＜0.05) but did notcorrelate significantly with lymph node metastasis (lymph nodemetastasis versus non-lymph node metastasis, P＞0.05); Rbgene protein positive-expression rate in tumor tissues was50.0 %, which was also lower than that in adjacent pancreatictissues (78.1%) (x2=5.497, P＜0.05); PCNA positive-expression rate was 71.9 %, being higher than that inadjacent pancreatic tissues (43.8 %) (x2=5.189, P＜0.05),PCNA positive-expression also correlated significantly withtumor cell differentiation and lymph node metastasis (well-differentiation versus moderate or low- differentiation, lymphnode metastasis versus non-lymph node metastasis, P＜0.05).Rb protein positive-expression rate in the tumor tissues ofp57kip2 protein positive-expression group was 53.3 %; andRb protein positive-expression rate in the tumor tissues ofp57kip2 protein negative-expression group was 47.1%. Therewas no significant relationship between the two groups(r=0.16507, P＞0.05).CONCLUSION: The decreased expression of p57kip2, Rbprotein or over-expression of PCNA protein might contributeto the genesis or progression of pancreatic cancer, p57kip2,Rb protein and PCNA may play an important role in genesisand progression of pancreatic cancer.
AIM:To investigate the effects of inhibiting factor of cell cycle regulation p57^(kip2),retinoblastinoma protein(Rb protein) and proliferating cell nuclear antigen(PCNA)in the genesis and progression of human pancreatic cancer. METHODS:The expression of p57^(kip2),Rb protein and PCNA in tumor tissues and adjacent tissues of 32 patients with pancreatic cancer was detected with SP immunohistochemical technique. RESULTS:p57^(kip2)protein positive-expression rate in tumor tissues of pancreatic cancer was 46.9 %,which was lower than that in adjacent pancreatic tissues(75.0 %)(X^2=5.317, P<0.05),p57^(kip2)protein positive-expression correlated significantly with tumor cell differentiation(well-differentiation versus moderate or low-differentiation,P<0.05)but did not correlate significantly with lymph node metastasis(lymph node metastasis versus non-lymph node metastasis,P>0.05);Rb gene protein positive-expression rate in tumor tissues was 50.0 %,which was also lower than that in adjacent pancreatic tissues(78.1%)(X^2=5.497,P<0.05);PCNA positive- expression rate was 71.9 %,being higher than that in adjacent pancreatic tissues(43.8 %)(X^2=5.189,P<0.05), PCNA positive-expression also correlated significantly with tumor cell differentiation and lymph node metastasis(well- differentiation versus moderate or low-differentiation,lymph node metastasis versus non-lymph node metastasis,P<0.05). Rb protein positive-expression rate in the tumor tissues of p57^(kip2)protein positive-expression group was 53.3 %;and Rb protein positive-expression rate in the tumor tissues of p57^(kip2)protein negative-expression group was 47.1%.There was no significant relationship between the two groups (r=0.16507,P>0.05). CONCLUSlrON:The decreased expression of p57^(kip2),Rb protein or over-expression of PCNA protein might contribute to the genesis or progression of pancreatic cancer,p57^(kip2), Rb protein and PCNA may play an important role in genesis and progression of pancreatic cancer.
