葛根素致急性血管内溶血5例临床分析

Clinical analysis of 5 cases with acute intravascular hemolysis caused by puerarin

目的 :总结葛根素致急性血管内溶血的临床病例特点 ,为临床今后预防和诊断治疗提供帮助。方法 :对临床所见 5例静脉应用葛根素治疗中发生急性溶血的病例进行临床分析。结果 :所有病例均有反复用药史 ,发生急性溶血前有前驱先兆症状 ;急性血管内溶血的特点是在静脉应用葛根素中 ,突然发生腰腹疼痛、寒战、发热、呼吸困难、一过性意识丧失、尿色加深或血尿、血色素下降、网织红细胞升高、直接抗人球蛋白试验阳性。结论 :临床凡遇到应用葛根素突然出现上述临床症状者 ,就应考虑急性血管内溶血发生 ,应立即停药 ,给予积极治疗。

Objective :To explore the clinical characteristics of acute intravascular hemolysis caused by puerarin so as to help our prevention, diagnosis and treatment.Methods: Analysis of 5 cases of acute intravascular hemolysis caused by puerarin was made and literature review conducted.Results: All patients had the history of administering puerarin, with the pre symptoms of acute hemolysis; the clinical characteristics of acute intravascular hemolysis were observed:sudden attacks of lumber and abdominal pain, chill, fever dyspnea, temporary conciousness loss, dark urine or hematuria, low hemoglobin, high reticular red blood cell, positive of Coombs'test. Conclusion: when sudden attacks of the above symptoms appear, the acute intravascular hemolysis should be taken into consideration first,and the giving of the puerarin intravenously be immediately stopped Active and proper treatment should be made.