子宫腺肌病患者血清白细胞介素-6水平的检测

Evaluation of interleukin-6 levels in serum of patients with Adenomyosis

目的了解子宫腺肌病患者血清IL 6水平及其意义。方法用酶联免疫吸附法(ELISA)测定子宫腺肌病患者 (30例 )、子宫肌瘤患者 (2 0例 )及健康成年女性 (1 5例 )血清IL 6水平。结果子宫腺肌病组血清IL 6水平 (99.0 6± 6 1 .30pg/ml)显著高于子宫肌瘤组 (2 4 .33±1 3.6 0 pg/ml,P <0 .0 1 )及健康成年女性组 (4 .91± 4 .73pg/ml,P <0 .0 1 )。子宫腺肌病组中增生期血清IL 6水平 (1 0 1 .0 0± 6 6 .0 9pg/ml)与分泌期 (95 .71± 5 4 .92 pg/ml)比较 ,无显著意义 (P >0 .0 5 )。 结论子宫腺肌病患者体内存在IL 6的高水平状态 。

Objective To evaluate the level of interleckin 6 in serum of patients with adenomyosis (AM). Methods The IL 6 lveels in serum obtained from 28 AM patients and 24 gynecological benign disease controls and 15 normal controls were determined by ELISA. Results IL 6 in patients with adenomyosis (99.06±61.30pg/ml) was significantly higher than that in controls (24.33±13.60pg/ml and 4.91±4.73pg/ml). When compared with secretory phage (95.71±54.92ph/ml), the level of IL 6 in proliferative phage in AM (101.00±66.09pg/ml) did not change significantly. Conclusion Over expression if IL 6 can augment the growth and secretion of adenomyosis cells.