脾脏原发性非霍奇金淋巴瘤临床病理研究

Clinicopathological study of primary non -Hodgkin’sly mphoma of the spleen

目的 探讨脾脏原发性非霍奇金淋巴瘤的临床表现、病理特征及治疗预后。方法 收集 1987～ 2 0 0 2年间 6例脾脏原发性非霍奇金淋巴瘤并复习相关文献。结果 脾脏原发性非霍奇金淋巴瘤主要的临床表现有 :左上腹疼痛、乏力、脾脏肿大、全血细胞减少、骨髓象改变 ;所有病人均施行了脾脏切除术和化疗 ,生存时间为 10个月至 15年 ;均为B细胞性 ,未见T细胞性 ;免疫组化结果 :CD2 0 、CD79a、LCA 3例均为强阳性 ,CD684例阳性 ,CD45RO、CD3 、CD566例均为阴性。结论 脾脏原发性非霍奇金淋巴瘤的治疗主要采取脾脏切除术并辅以化疗或放疗 。

Objective Toinvestigatetheclinicalpathologicalfeatures ,effectofsurgicaltreatmentandprognosisinspleenprimarynon - Hodgkin’slymphoma(SPNHL) .Methods 6casesofSPNHLpatientsbetween 1987～ 2 0 0 2weredescribedwithreviewoftheliterature .Results ThemajorclinicalsymptomsofSPNHLincluding :leftupperabdominopain ,weakness ,splenomegalia ,completebloodcountdecreased ,bonemar rowimagingchanged .Allpatientshadsplenectomyandchemotherapyandsurvived 10monthto 15years .PathologicalchangesmostlyfoundinB cellgenicnotT -cellgenic ,immunohistochemicalstainsmarkerCD2 0 、CD79a、LCApresentstrong( +)in 3cases ,CD68( +)in 4cases ,CD45RO、 CD3 、CD56( -)in 6case .Conclusions themajortreatmentofSPNHLincludingsplenectomyandadditionalchemotherapyorradiotherapywillim provedpatient’ssurvival.