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不同剂量的沙丁胺醇对慢性阻塞性肺疾病患者支气管舒张试验结果的影响 被引量:8

The Effects of Different Amount of Albuterol on COPD Patients Bronchodilation Test
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摘要 目的 比较慢性阻塞性肺疾病 (COPD)患者吸入 2 0 0 μg与 40 0 μg喘乐宁进行支气管舒张试验结果的一致性。方法 采用随机、交叉、自身对照方法对 40例COPD患者吸入 2 0 0 μg、40 0 μg喘乐宁进行支气管舒张试验 ,比较一秒钟用力呼气容积 (FEV1)绝对值的改变量、FEV1改善率、弥散 (DLCO)改善率、气道阻力 (Raw)改善率、呼气流速峰值 (PEF)改善率、舒张试验阳性率。结果 COPD患者吸入 2 0 0 μg、40 0 μg喘乐宁进行支气管舒张试验 ,两个剂量组FEV 1绝对值改变量、FEV1改善率、DLCO改善率、Raw改善率、PEF改善率、舒张试验阳性率比较差异均无显著性。急性发作期COPD患者FEV1绝对值改变量、FEV1改善率、舒张试验阳性率均高于稳定期COPD患者 (P <0 .0 0 1)。结论 吸入 2 0 0 μg喘乐宁既可保证舒张试验的效能 ,又可减少药物用量和减轻药物副作用 ,是一理想的选择。 Objective To compare consistency of 200μg and 400μg albuterol as bronchodilator in pulmonary function test in COPD patients.Methods 40 COPD patients were included in this study.Each patient inspired 200μg and 400μg albuterol in random order.The pulmonary functions were evaluated in the changing amount of FEV 1,improving rates of FEV 1,PEF,Raw,D LCO and positive rate.Results The changing amount of FEV 1, improving rates of FEV 1,PEF,Raw,D LCO and positive rate were not significantly different between COPD patients inspiring 200μg and 400μg albuterol.The changing ammount of FEV 1, improving rates of FEV 1, and positive rate of COPD patients were higher in exacerbation than stability(P<0.001).Conclusion The amount of bronchodilator need to be nationwidely unified. 200μg albuterol is the perfect choice as it possesses high efficiency and less side effects.
出处 《临床内科杂志》 CAS 北大核心 2004年第5期322-324,共3页 Journal of Clinical Internal Medicine
关键词 慢性阻塞性肺疾病 支气管舒张试验 沙丁胺醇 肺功能 COPD Bronchodilation Albuterol Pulmonary function
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