单配制啮齿动物PairBond形成的神经调节机制(英文)

Neural Regulation of Pair Bond Formation in a Monogamous Rodent Species

单配制啮齿动物社会结构的神经生物学原理可以通过实验室研究Socialbonding而获得。在本文中,我们探讨了如何利用单配制的草原田鼠(Microtusochrogaster)作为研究模型揭示pairbond形成的神经调控机制。我们进而探讨了单配制与多配制田鼠之间神经解剖学的差异以及神经化学物质的调节是怎样影响pairbond的。本篇综述还讨论了与pairbond形成有关的神经化学系统之间的相互影响以及pairbond形成过程中的两性差异。最后,我们预测了这一研究领域的未来研究方向以及研究socialbonding的神经调控对人类健康的重要性。

The neurobiology of monogamous social organization can be studied by laboratory examination of social bonding. In this review, we discuss how the monogamous prairie vole (Microtus ochrogaster) has been used as a model system to provide tremendous insight into the neural regulation of pair bond formation. Neuroanatomical differences between monogamous and non-monogamous voles, as well as how neurochemical manipulations affect pair bond formation are reviewed. In addition, interactions among neurochemical systems that regulate pair bond formation and the extent of sexual dimorphism associated with pair bonding are discussed. Finally, we propose future directions for this line of research and explain why understanding the neural regulation of social bonding is important for human health.