摘要
免疫因素是引起男性不育的原因之一。由于抗原 (Ag)所在部位、分子量大小和结构各异 ,精子Ag在免疫性不育中所起的作用不同。抗精子抗体 (AsAb)可直接作用于精子或通过改变局部微环境而间接影响精子功能。本文就精子Ag多样性、AsAb作用部位和机制、AsAb类别及滴度对生育的影响作一综述。
Immune factors account for 5%～15% of male infertility. Becuase of the diversity in molecular weight, structure and location, sperm antigens play different roles in immune infertility. Antisperm antibodies(AsAb) influence sperm function not only by direct action, but also by changing the local microenvironment indirectly. This paper reviews the progress in the studies of the implication of human sperm antigens, the function, mechanisms, categories and titer of AsAb in male infertility.
出处
《中华男科学杂志》
CAS
CSCD
2004年第5期385-388,390,共5页
National Journal of Andrology
关键词
精子抗原
抗精子抗体
免疫性不育
sperm antigen
antisperm antibodies
immune infertility
