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奥氮平对精神分裂症患者睡眠脑电活动的影响 被引量：12

Effects of olanzapine on sleep in patients with schizophrenia
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摘要 目的:应用多导睡眠图探讨奥氮平对精神分裂症患者睡眠脑电活动的影响。 方法:对13例精神分裂症患者连续进行3个晚上多导睡眠图检查,其中第2、3晚上睡前予10mg奥氮平,观察用药后多导睡眠图的变化。正常对照组14名,作2夜基础多导睡眠图监测。结果:精神分裂症患者服用奥氮平后睡眠进程和睡眠总时间有所改善,觉醒时间减少和S1缩短,S2和慢波睡眠(S3、S4)显著增加,而快速眼动(REM)时间和潜伏期未见明显变化。结论:奥氮平能增加睡眠总时间,改善睡眠质量,这可能与奥氮平拮抗5鄄羟色胺能神经元作用相关。 Objective To analyze the effects of olanzapine on the polysomnography in patients with schizophrenia. Methods State of sleep in 13 patients with schizophrenia were examinde by polysomnography(PSG) for 3 consecutive nights and in the last two nights, the patients were given olanzapine bofore sleeping. Results Sleep process and total sleep time in the patients improved after taking olanzapine. Furthermore, the stage 1 of sleep was decreased and stage 2, 3, 4 were significantly prolonged, while time of rapid eye movement (REM) and latency were no significantly changed after medication. Conclusion Olanzapine may improve the total sleep time and sleep quality in patients with schizophrenia, and its effect might be related with the effects of anti-5-HT.
作者 张明岛 陈兴时 王红星 王祖承 白培深 楼翡缨
机构地区 上海市精神卫生中心上海市精神卫生研究所 上海第二医科大学精神医学教研室 上海第二医科大学精神医学教研室 山西医科大学第一医院精神科
出处 《诊断学理论与实践》 2004年第2期103-105,共3页 Journal of Diagnostics Concepts & Practice
关键词 奥氮平 精神分裂症 睡眠 脑电活动 药物治疗 Olanzapine Schizophrenia Polysomnography Slow-wave sleep
分类号 R749.3 [医药卫生—神经病学与精神病学] R971.41 [医药卫生—药品]
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参考文献12

  • 1[1]Keshavan MS,Reynolds CF 3rd,Miewald MJ,et al.Delta sleep deficits in schizophrenia:evidence from automated analyses of sleep data[J].Arch Gen Psychiatry,1998,55(5) :443-448.
  • 2[2]Maixner S,Tandon R,Eiser A,et al.Effects of antipsychotic treatment on polysomnographic measures in schizophrenia:a replication and extension[J].Am J Psychiatry,1998,155(11):1600-1602.
  • 3[3]Lauer CJ,Krieg JC.Slow-wave sleep and ventricular size:A comparative study in schizophrenia and major depression[J].Biol Psychiatry,1998,44(2):121-128.
  • 4[4]Lindberg N,Virkkunen M,Tani P,et al.Effect of a single-dose of olanzapine on sleep in healthy females and males[J].Int Clin Psychopharmacol,2002,17(4):177-184.
  • 5张明岛,陈兴时,王红星,王祖承,白培深,楼翡缨.奥氮平对精神分裂症患者睡眠脑电活动的影响[J].诊断学理论与实践,2004,3(2):103-105. 被引量：12
  • 6[7]Rechtschaffen A,Kales A.A manual of standardized terminology,techniques,and scoring system for sleep stages in human subjects[M].California:Brain Information Service/Brain Institute,1968.3-7.
  • 7[8]Keshavan MS,Pettegrew JW,Reynolds CF,et al.Biological correlates of slow wave sleep deficits in functional psychoses:31P-magnetic resonance spectroscopy[J].Psychiatry Res,1995,57(2):91-100.
  • 8[9]Kapur S,Zipursky RB,Remington G.Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine,risperidone,and olanzapine in schizophrenia[J].Am J Psychiatry,1999,156(2):286-293.
  • 9[10]Sharpley AL,Vassallo CM,Cowen PJ.Olanzapine increases slow-wave sleep:evidence for blockade of central 5-HT2c receptors in vivo[J].Biol Psychiatry,2000,47(5):468-470.
  • 10[11]Lerer B,Macciardi F,Segman RH,et al.Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder[J].Mol Psychiatry,2001,6(5):579-585.

二级参考文献12

  • 1[1]Keshavan MS,Reynolds CF 3rd,Miewald MJ,et al.Delta sleep deficits in schizophrenia:evidence from automated analyses of sleep data[J].Arch Gen Psychiatry,1998,55(5) :443-448.
  • 2[2]Maixner S,Tandon R,Eiser A,et al.Effects of antipsychotic treatment on polysomnographic measures in schizophrenia:a replication and extension[J].Am J Psychiatry,1998,155(11):1600-1602.
  • 3[3]Lauer CJ,Krieg JC.Slow-wave sleep and ventricular size:A comparative study in schizophrenia and major depression[J].Biol Psychiatry,1998,44(2):121-128.
  • 4[4]Lindberg N,Virkkunen M,Tani P,et al.Effect of a single-dose of olanzapine on sleep in healthy females and males[J].Int Clin Psychopharmacol,2002,17(4):177-184.
  • 5[7]Rechtschaffen A,Kales A.A manual of standardized terminology,techniques,and scoring system for sleep stages in human subjects[M].California:Brain Information Service/Brain Institute,1968.3-7.
  • 6[8]Keshavan MS,Pettegrew JW,Reynolds CF,et al.Biological correlates of slow wave sleep deficits in functional psychoses:31P-magnetic resonance spectroscopy[J].Psychiatry Res,1995,57(2):91-100.
  • 7[9]Kapur S,Zipursky RB,Remington G.Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine,risperidone,and olanzapine in schizophrenia[J].Am J Psychiatry,1999,156(2):286-293.
  • 8[10]Sharpley AL,Vassallo CM,Cowen PJ.Olanzapine increases slow-wave sleep:evidence for blockade of central 5-HT2c receptors in vivo[J].Biol Psychiatry,2000,47(5):468-470.
  • 9[11]Lerer B,Macciardi F,Segman RH,et al.Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder[J].Mol Psychiatry,2001,6(5):579-585.
  • 10[12]Sharpley AL,Vassallo CM,Pooley EC,et al.Allelic variation in the 5-HT2C receptor(HT2RC) and the increase in slow wave sleep produced by olanzapine[J].Psychopharmacology(Berl),2001,153(2):271-272.

共引文献11

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二级引证文献78

诊断学理论与实践
2004年 第2期

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