摘要
本文通过对38例AMI 患者定时测定CK-MM 亚型和MM_3/MM_1值,与18例正常体检者(对照组一)和7例心绞痛患者(对照组二)相比较,结果显示CK-MM 亚型及其比值是血清酶谱中上升最快、恢复最早的一项指标。正常人MM_161.8±7.8%;MM_228.7±7.5%;MM_39.5±4.6%,顺序为MM_1>MM_2>MM_3。MM_3/MM_1正常值为0.18±0.12。在AMI 后0～4小时,MM_3明显升高,常大于20%,MM_3/MM_1>1;在4～8小时,MM_3>40%,呈MM_3>MM_2>MM_1,MM_3/MM_1达3.88±1.93。在8～20小时均以MM_2为主要成份,MM_3/MM_1仍大于1。在20～24小时,CK-MM 亚型及其比值均恢复正常。观察其在AMI 发病后不同时间的有规律变化,可推算出发病时间,对AMI 的早期诊断和及时给予溶栓治疗有很大价值。
Plasma MM-Creatine Kinase lso-forms(CK-MM)and the ratio of MM_3/MM_1 were measured in 38 cases ofAMI,18 cases of normal individuals (the First Control Group)and in 7cases of angina pectoris(the SecondControl Group).The normal rangeof CK-MM isoforms of the firstcontrol group were MM_1 61.8%±7.6%,MM_228.7%±7.5%,MM_39.5±4.6% respectively,and in a orderlymagnitude MM_1>MM_2>MM_3.Thenormal ratio of MM_3/MM_1 is 0.18±0.12.At the onset of AMI,MM_3predominantely increased hours to 20%and MM_3/MM_1 ratio greater than 1within 0-4 hours.Following 4-8hours,MM_3 increased to more than40%,the magnitude of orderreversed as MM_3>MM_2>MM_1,andthe ratio MM_3/MM_1 reached 3.88±1.93.After 8-20 hours,the MM_3/MM_1 ratio remained greater than 1,the MM_2 came to be the main com-ponent in the plasma.After 20 hoursCK-MM isoforms and MM_3/MM_1 re-stored to normal。The study indicates that CK-MMisoforms and the ratio of their com-ponents in the serum enzymes showvery rapid incrase and earlier resto-ration to normal in AI.The sequen-tial changes of these serum enzymescan be utilized as early diagnosis ofthe time onset of AMI,as well as fordetermination of reperfusion of coro-nary artery in thrombolytic therapy.
