摘要
本文比较了钙拮抗剂硝苯吡啶与尼群地平对慢性充血性心力衰竭(CHF)的临床疗效。结果发现,两药显效率及总有效率相似。两药均使血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)及肌红蛋白(Mb)水平下降。硝苯吡啶能增加血浆肾素活性(PRA),尼群地平则使PRA 降低。
The effects of two calcium antagonists nitfedipine and nitrendipineon 30 cases of chronic congestiveheart failure(CHF)were studied.Thepatients were divided randomly intotwo groups.After 5 weeks therapywith each agent,all the patientsexperienced improvement of the classof cardiac function(NYHA classification).The total effect rate of thetwo agents were simillar(100% vs100%, P>0.05).The blood plasmaangiotensin Ⅱ,aldosterone and myoglobin were decreased significantlyby each agent.plasma renin activity(PRA)was increased by nifedipine(0.59±0.20 vs 1.02±0.27μg/L·h,P<0.01)and decreased by nitrendipine(2.21±0.30 vs 1.06±0.26μg/L·h,P<0.01).The study indicats that dothnifedipine and nitrendipine are effective in the treatment of CHF.The two agents have different effecton PRA.
