骨科抗感染预防用药138例的药物经济学分析

A pharmacoeconomic analysis of preventive medication applied against clinical infection in 138 orthopaedic patients

目的 观察不同方案对骨科手术后抗感染预防用药的疗效及所发生的经济效果。方法 骨科手术病人 138例 ,类伤口 ,术前无感染指征。随机分为 6组 ,给予不同的治疗方案 ,观察其手术后治疗结果 ,并运用药物经济学的成本 效果分析进行评价。结果 青霉素G Na作骨科抗感染预防用药 ,其C/E值明显小于其他治疗组。结论 6组方案中 ,青霉素为最佳选择 ,其余依次为氧氟沙星、头孢拉定、头孢噻肟钠、头孢呋辛、头孢三嗪。

Objective To investigate the curative effect along with the resulting economic effect of preventive medication applied against clinical infection after orthopaedic surgery.Methods Different orthopaedic surgeries were divided into 6 groups stochastically and received different therapeutic schemes.No infection signs were found in the analogous wounds before the surgical management.We observed the therapeutic results after surgeries and assessed such results with cost effectiveness analysis(CEA).Results It was noted that the value of cost/effectiveness(C/E) of penicillin G Na was far more less than that of the other therapeutic groups when it was applyed as prevalent drug against clinical infection in orthopaedics.Conclusion There was no statistical significance in the difference of curative effects among the therapeutic groups.Therefore,in these 6 therapeutic schemes,penicillin was the optimal choose,followed by penicillin,ofloxacin,cefradine sodium,cefuroxime sodium,recophin.