肿瘤性贫血病人血清促红细胞生成素和睾酮水平的研究

Study on the serum erythropoietin and testosterone in patients with anemia of cancer

目的 研究血清促红细胞生成素 (EPO)和睾酮 (T)与肿瘤性贫血的关系。方法 用ELISA法及放射免疫法测定肿瘤性贫血病人血清EPO和T的水平 ,并与正常对照及化疗前后比较。结果 肿瘤性贫血病人血清EPO含量 (2 78± 0 73μg/ml)显著高于正常对照 (1 6 0± 0 5 6 μg/ml) ,P <0 0 1,于化疗后升高更显著 ;而血清睾酮的水平 (16 6± 7 86nmol/L)显著低于正常对照 (19 18± 9 6 9nmol/L) ,且化疗后降低更明显。结论 肿瘤性贫血病人内源性EPO水平升高 ,睾酮水平下降 。

Objective To investigate the change of serum erythropoietin and testosterone in patients with anemia of cancer.Methods Levels of EPO and testosterone were detected with the ELISA and radio immunoassay.Results Serum EPO level in anemia of cancer was 2.78±0.73μg/ml,wich was significantly higher than those in normal controls(1.60±0.56μg/ml) and increased greatly after chemotherapy.While the serum testosterone level in anemia of cancer(16.6±7.86nmol/L) reduced significantly compared with those in normal controls(19.18±9.69nmol/L).Conclusion There was a increased endogenous EPO levels with a decreased testosterone levels in patients with anemia of cancer,chemotherapy and testosterone may be effective for treatment anemia of cancer.