MDR1、MRP基因产物在星形细胞瘤中的表达及其意义

Expression of MDR1 and MRP in human astrocytomas and its significance

目的 探讨星形细胞瘤中MDR1及MRP基因表达及其临床意义。方法 用免疫组织化学SP法检测 5 8例星形细胞瘤中MDR1及MRP基因产物的表达。结果 MDR1、MRP在星形细胞瘤中高度表达 ,阳性表达率分别为 84.5 %和 60 .3 %;两者在正常脑组织中无阳性表达 ,差异有非常显著性 (P <0 .0 1)。两者在低度恶性星形细胞瘤 (包括Ⅰ级和Ⅱ级 )和高度恶性星形细胞瘤 (包括Ⅲ级和Ⅳ级 )中的表达相互比较 ,差异有非常显著性 (P <0 .0 1)。结论 MDR1、MRP基因编码的P gp和MRP蛋白在星形细胞瘤多药耐药机制中起重要作用。通过抑制P gp和MRP蛋白的表达可能找到逆转脑胶质瘤化疗多药耐药的方法。

ObjectiveTo investigative the expression of the MDR1 and MRP in astrocytomas and find the correlation between them.MethodsMDR1 and MRP protein expression was deteced in 58 astrocytomas and 8 normal brain specimens by immunohistochemistry.ResultsMDR1 and MRP were highly expressed in astrocytomas with the positive expression rate being 84.5% and 60.3% respectively,but both of them were not detectable in normal brain tissues ( P <0.01).The immunoreactive score of MDR1 and MRP was significantly higher in high-grade astrocytomas than low-grade astrocytomas ( P <0.01).CouclusionThe expression of MDR1 and MRP may be important in the process of multidrug resistance in astrocytomas.A potential role of MDR1 and MRP inhibitors as an adjuvant therapy for glioma may exist.