转移性肾癌的免疫化学疗法

Immunotherapy of metastatic renal cell carcinoma :report of 28 cases

目的 观察免疫化学疗法对转移性肾癌的治疗效果。方法 对 2 8例转移性肾癌患者进行免疫化学疗法 ,白细胞介素 2为每次 5～ 2 0MU/m2 ,每周 3次皮下注射 ;干扰素为每次 6～ 9MU/m2 ,每周 3次皮下注射 ;氟铁龙为 80 0～ 12 0 0mg/d ,分 2～ 3次口服。 结果 2 8例患者中完全缓解 (CR) 4例 (14 3% ) ,部分缓解 (PR) 9例 (32 1% ) ,总有效率 (CR +PR) 4 6 4 %。

Objective To determine the efficacy of IL 2,IFN and Furtulon in patients with metastatic renal cell carcinoma Methods During the induction phase of the treatment of 28 patients,which lasted 3 months,IL 2 and IFN were administered subcutaneously three times a week at doses of 5～20MU/m 2 and 6～9 MU/m 2,Furtulon was administered at doses of 800～1 200 mg daily by oral during 28 days a month Results The response rate was 46 4%,including 4 complete response(CR),9 presented with partial response (PR) Conclusion The three drugs combination described in this study demonstrates activity Based on the present data,combined biochemotherapy may be a promising new approach to the therapy of the metastatic renal cell carcinoma