冠心病患者氧化型低密度脂蛋白自身抗体与高敏C-反应蛋白的关系

Relationship between autoantibodies against oxidized low-density lipoprotein and high-sensitivity C-reactive protein in patients with coronary artery disease

目的 探讨氧化型低密度脂蛋白自身抗体 (oxLDL Ab)、高敏C 反应蛋白 (hs CRP)与冠心病之间的关系以及oxLDL Ab与hs CRP之间的相关性。 方法 对 6 1例确诊的冠心病患者、116例高血压病患者和 12 3名健康对照进行血清oxLDL IgG、IgM和hs CRP水平进行检测 ,并作相关性分析。结果 冠心病患者oxLDL IgG 2 1 4 8(17 5 8～ 2 9 0 1)U/L、oxLDL IgM 4 71(3 88～ 7 0 6 )U/L和hs CRP 3 2 7(1 32～ 6 80 )mg/L均显著高于高血压组 15 93(11 12～ 2 2 2 6 )U/L、2 5 4 (1 17～ 5 0 5 )U/L、0 79(0 4 2～ 1 87)mg/L和健康对照组 11 12 (4 70～ 16 5 7)U/L、1 6 1(0 6 0～ 3 0 3)U/L、0 74 (0 4 8～1 5 0 )mg/L ,P均 <0 0 0 1,而hs CRP在高血压病组和健康对照组之间差异无显著意义 ,P >0 0 5。在这3组中均未发现oxLDL Ab与hs CRP之间有相关性。 结论 oxLDL Ab与hs CRP在冠心病患者中显著升高且无明显相关性 ,提示二者在冠状动脉硬化进程中可能各自起着重要的作用。

Objective To evaluate the relationship between autoantibodies against oxidized low density lipoprotein(oxLDL-Ab) and high-sensitivity C-reactive protein(hs-CRP) in coronary artery disease(CAD). Methods Serum samples were taken from 61 patients with CAD,116 patients with essential hypertension(EH) and 123 control individuals. The levels of oxLDL-Ab and hs-CRP were quantitatively analyzed. Results The patients with CAD had significantly higher levels of oxLDL-IgG 21.48 (17.58～29.01)U/L, oxLDL-IgM 4.71 (3.88～7.06) U/L and hs-CRP 3.27 (1.32～6.80) mg/L than EH group 15.93 (11.12～22.26)U/L, 2.54 (1.17～5.05)U/L, 0.79 (0.42～1.87) mg/L and healthy control group 11.12 (4.70～16.57)U/L, 1.61 (0.60～3.03)U/L, 0.74 (0.48～1.50) mg/L. (P<0.001). There was no significant difference in the serum hs-CRP betweenthe EH group and the control group(P>0.05).There was no association between oxLDL-IgG or IgM and hs-CRP among the three groups. Conclusion These results partially show that the relation of chronic inflammation, autoimmunity and CAD. oxLDL-Ab and hs-CRP respectively maybe play an important role in the development of atherosclerosis.