期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

药用质粒DNA下游加工工艺研究进展 被引量：1

Advance in downstream processing of pharmaceutial plasmid DNA
下载PDF
导出
摘要 论述了药用质粒DNA的质量要求和其下游加工工艺研究进展,并以色谱制备工艺为例,介绍了下游加工工艺中影响药用质粒DNA质量的因素。 The quality assurance of pharmaceutical plasmid DNA and advance in its downstream processing are overviewed in this article. The factors influencing the quality of pharmaceutical plasmid DNA in downsream processing are also discussed here by taking chromatography preparation for exmaple.
作者 程从升 涂长春
机构地区 解放军军需大学军事兽医研究所
出处 《生物技术通讯》 CAS 2004年第2期154-157,共4页 Letters in Biotechnology
基金 国家八六三高计划研究基金项目(2001AA213141)
关键词 药用质粒DNA 加工工艺 质量 DNA疫苗 基因治疗 分离 pharmaceutical plasmid DNA quality downstream processing inflencing factor
分类号 R392-33 [医药卫生—免疫学]
  • 相关文献

参考文献29

  • 1Giovannini R,Freitag R,Tennikova TB.High-performance membrane chromatography of supercoiled plasmid DNA[J].Anal Chem,1998,70(16):3348
  • 2Durlans RH,Eastman EM.Manufacturing and quality control of plasmid-based gene expression systems[J].Adv Drug Delivery Reviews,1998,30(1-3):33
  • 3Ferreira GNM,Monteiro GA,Prazeres DMF,et al.Downstream processing of plasmid DNA for gene therapy and DNA vaccine applications[J].Trends Biotechnol,2000,(18):380
  • 4US FDA Guideline.Guidance for industry-guidance for human somatec cell therapy and gene therapy[Z].1998
  • 5Lander RJ,Winters MA.Fractional precipitation of plasmid DNA from lysate by CTAB[J].Biotechnol Bioeng,2002,79(7),776
  • 6Levy MS,Collins IJ,Tsai JT,et al.Removal of contaminant nucleic acids by nitrocellulose filtration during pharmaceutical-grade plasmid DNA processing[J].J Biotechnol,2000,76(2-3):197
  • 7Lahijani R,Hulley G,Soriano G,et al.High yield production of pBR322-derived plasmids intended for human gene therapy by employing a temperatur-controllable point mutation [J].Hum Gene Therapy,1995,7(16):1971
  • 8Carlson A.Mechanical disruption of Escherichia coli for plasmid DNA recovery[J].Biotechnol Bioeng,1995(48):303
  • 9Theodossipn L The processing of plasmid based gene from Escherichia cali:primary recovery by filtration[J].Bioprocess Eng,1997,(16):175
  • 10Eon-Duval A,Gumbs K,Ellet C.Precipitation of RNA impurities with high salt in a plasmid DNA purification process:use of experimental desigen to determine reaction conditions [J].Biotechnol Bioeng,2003,83(5):544

二级参考文献16

共引文献24

同被引文献20

  • 1Wolff J A,Malone R W,Williams P,et al.Direct gene transfer into mouse,muscle in vivo[J].Science,1990,247:1465-1468.
  • 2Wolff J A,Danko I.Direct gene transfer into muscle[J].Vaccine,1994,2(16):1499-1502.
  • 3Donnelly J J,Fridman A,Martinez D,et al.Preclinical efficacy of a prototype DNA vaccine:enhanced protection against antigenic drift in influenza virus[J].Nat Med,1995,1(6):583-587.
  • 4Dannelly J L,Wabren B,Liu M A.DNA vaccines:progress and challenges[J].J Immunol,2005,175:633-639.
  • 5Sedegah M,Jones T R,Kanr M,et al.Boosting with recombinant vaccinia increases immunogenicity and protective efficacy of malaria DNA vaccine[J].Proc Natl Acad SCi USA,1998,95:7648-7653.
  • 6Hall R A,Nisbet D J,Pham K B,et al.DNA vaccine coding for the fulllength infectious Kunjin virus RNA protects mice against the New York strsin of West Nile virus[J].Proc Natl Acad Sci USA,2003,100:10460-10464.
  • 7Hermanson G,Whitlow V,Parker S,et al.A cationic lipid-formulated plasmid DNA vaccine confers sustained antibody-mediated protection against aerosolized anthrax spores[J].Proc Natl Acad Sci USA,2004,101:13601-13606.
  • 8Stevenson F K,Ottensmeier C H,Johnson P,et al.A DNA vaccines to attack cancer[J].Proc Natl Acad Sci USA,2004,101:14646-14652.
  • 9Yamanka H,Hoyt T,Bowen R,et al.An IL-12 DNA vaccine co-expressing Yersinia pestis antigens protects against pneumonic plague[J].Vaccine,2009,27:80-87.
  • 10Cheng L,Ziegalhoffer P R,Yang N S,et al.In vivo promoter activity and transgene expression in mammalian somatic tissue evaluated by using particle bombardment[J].Proc Natl Acad Sci USA,1993,90:4455-4459.

引证文献1

二级引证文献1

生物技术通讯
2004年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部