L-精氨酸对偏头痛患者血浆一氧化氮、内皮素含量的影响及临床意义

Effect and Clinical Significance of L-Arg to the Migraine Patient’s Plasma Nitricoxide and Edotheline

目的 探讨L -Arg对偏头痛患者血浆NO、ET含量变化的影响及其临床意义 ,为防治偏头痛的发生发作提供依据。方法 NO测定采用分光光度法 ,ET用放射免疫法。结果 偏头痛患者血浆NO、ET含量均高于对照组 ,两组注射L -Arg与未注射L -Arg血浆NO含量有非常显著性差异 (P<0 .0 1) ,而ET基本无变化。结论 偏头痛发生发作可能与L -Arg/NO通路活动增强有关 ,L -Arg增加抑制血管内皮细胞释放ET是偏头痛加剧的因素之一。

Objective Probed the effect and clinical significance of L-Arg to migraine patient’s plasma NO and ET changing, which offered evidence of preventing the migraine occurrence. Methods Spectrophotometry was taken to test NO, radioimmunity was taken to test ET. Results Migraine patient’s plasma NO, ET was higher than that in control group. Plasma NO between injected L-Arg group and disinjected L-Arg group was obviously different (P<0.01), and ET was no basic difference. Conclusions The migraine occurrence probably was relative to the strength of the L-arg/No iteral movement, L-Arg controlled hemoendothelial cells to set free ET, which was one of factors to prick up migraine.