单股正链RNA病毒基因组3′非编码区的高级结构与功能研究进展

The Progress in 3′ Untranslated Region of Single Strand Plus RNA Virus

单股正链RNA病毒种类繁多 ,其宿主涉及人、动物、植物 ,对人畜健康和农业经济生产都有重大的影响 .病毒基因组 3′UTR内的序列形成茎环、假结、TLS等高级结构 ,既可以作为顺式元件 ,又可以结合蛋白质反式因子 ,对病毒的转录、复制、翻译都有调控作用 .简要介绍了单股正链RNA病毒代表种属的 3′UTR内高级结构与功能的研究方法、主要进展和存在的问题 .

The results of many researches show that 3' untranslated region plays a very important role in the life cycle of single strand plus RNA virus. The high structures in 3'UTR such as stem-loop, pseudoknot AND tRNA-like structure are also generally believed to be partly involved into the transcription, replication and translation of plus-strand RNA virus. The common methods and the last results about 3'UTR of this kind of virus are reviewed.